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Data on the number of people in the US taking glucagon-like peptide-1 medications, both to reduce obesity and to help control diabetes, show a somewhat stable trend

This may indicate inadequate response to the medication, requiring dose adjustment, evaluation of administration technique, or consideration of alternative or adjunctive therapies

Metabolomics analysis has also shown that Chinese medicine can significantly alleviate depressive symptoms induced by CUMS and modulate biomarkers such as BDNF and the HPA axis [546]

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(138) showed that methionine metabolism gene expression was significantly altered in the gut microbiota of DKD patients

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