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It is a natural food and medicine, and it needs much attention as a health-oriented product
In the obese state, adiponectin levels decrease as leptin levels increase
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The HLA-DPB1 locus also contributes to risk, though its effect is less profound than the DR and DQ loci, with DPB1*0301 and DPB1*0202 associated with risk and DPB1*0402 acting as a protective allele in DR3 carrying patients (61)
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