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The human evidence for GLP-1 activation specifically is limited
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Of note, this trial employed an individualized titration schedule on a variety of background regimens, which is likely more applicable to typical clinical practice
CPT1A is known to be expressed in the liver, lymphocytes, and fibroblasts [18], but its expression and location in FLS are unknown
Therefore, it is necessary to understand how a variety of intrinsic and extrinsic factors are integrated to create the metabolic flexibility and to reduce the metabolic dependencies dictated by oncogenic signaling