Journal of the International Society of Sports Nutrition, The bright and the dark sides of L-carnitine supplementation: a systematic review
Raghavan S, Winter PS, Navia AW, Williams HL, DenAdel A, Lowder KE, Galvez-Reyes J, Kalekar RL, Mulugeta N, Kapner KS, Raghavan MS, Borah AA, Liu N, Vayrynen SA, Costa AD, Ng RWS, Wang J, Hill EK, Ragon DY, Brais LK, Jaeger AM, Spurr LF, Li YY, Cherniack AD, Booker MA, Cohen EF, Tolstorukov MY, Wakiro I, Rotem A, Johnson BE, McFarland JM, Sicinska ET, Jacks TE, Sullivan RJ, Shapiro GI, Clancy TE, Perez K, Rubinson DA, Ng K, Cleary JM, Crawford L, Manalis SR, Nowak JA, Wolpin BM, Hahn WC, Aguirre AJ, Shalek AK (2021) Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
Kabahizi A, Wallace B, Lieu L, Chau D, Dong Y, Hwang ES, Williams KW (2022) Glucagon-like peptide-1 (GLP-1) signalling in the brain: From neural circuits and metabolism to therapeutics
This is a chronic health condition, just like other things we treat, like hypertension, Moore said

Key Takeaways GLP-1 medications aren't causing gestational diabetes they may have been masking underlying metabolic dysfunction that becomes visible when the medication is stopped Thyroid problems can be "unmasked" by GLP-1 treatment because the medications signal to your brain that you're not starving, allowing the pituitary TSH to rise, sometime uncovering a pre-existing thyroid issue Zepbound may improve iron absorption if iron levels go too high, testing for hemochromatosis may be warranted To reduce injection site reactions: warm the medication to room temperature, clean and prep skin but don't over-rub with alcohol, inject at exactly 90 degrees, don't pinch the skin, and stay relaxed Diets cause fat regain at the cellular level it's chemistry, not willpower and the fat often accumulates in the visceral area around organs There's no need to increase your GLP-1 dose if you're making good progress an annual weight loss rate of 15% or higher is considered strong Notable Quote "You can't think that just because somebody's weight is high, it's because something they're doing is wrong

doi: 10.1016/j.foodres.2024.114000 69