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The potency of semaglutideits ability to activate GLP-1 receptors and produce the desired therapeutic effectsmay decline after the expiration date

13 Figure 25: SF-36v2 change from baseline at week 26, PIONEER 3 (FAS) CI = confidence interval

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doi: 10.1111/jnc.14336 22 MaJShiMZhangXLiuXChenJZhangRet al

In one of the earliest studies investigating these changes, chronic liraglutide treatment in rats with ad libitum access to both standard chow and sweet candies led to a reduction in total calorie intake

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