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Nature 527 , 186191 (2015)

Niacinamide pulls double duty by evening tone and limiting the amount of pigment that reaches the surface, while retinyl palmitate (a gentler vitamin A derivative also known as pro-retinol) supports cell turnover to gradually lift existing spots

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The RMSD of CME_a is relatively stable, while CME_b shows fluctuation during the first 200 ns (Fig