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Look for actual certification seals on the bottle, not vague claims about purity or quality. Side Effects and Safety Here are a few things to keep in mind: Standard berberine HCl can cause GI upset, such as nausea, cramping, and loose stoolsparticularly at higher doses and if not taken with food: The good news is that these side effects typically improve within a short amount of time, as your body adjusts

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Pay attention to signs of a possible infection, such as worsening pain, warmth, or pus, or the symptoms of an allergic reaction, like hives, difficulty breathing, or swelling of the face and throat

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Clinical trials have demonstrated substantial efficacy, with patients achieving A1c reductions of 1.9% to 2.4% in type 2 diabetes and weight loss averaging 15% to 21% of baseline body weight after 72 weeks in adults without diabetes (more modest in those with type 2 diabetes)

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