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The benefit-risk profile generally favors use in appropriate patients, particularly given the cardiovascular and metabolic benefits demonstrated in outcome trials

Annu Rev Biochem 45: 559604

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The dose schedule typically begins at 1mg weekly and escalates to 8mg or 12mg depending on the trial protocol

Gallbladder disease : increased risk of cholelithiasis and cholecystitis associated with rapid weight loss [21] [22] Hypoglycaemia : risk is low with GLP-1 monotherapy but increases when combined with insulin or sulphonylureas

For combination protocols where maximizing AOD 9604 effectiveness matters, injectable is strongly preferred