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Early preclinical studies in experimental diabetes demonstrated toxicities such as anemia, thrombocytopenia, splenomegaly, lymphadenopathy, lung histiocytosis, mortality with multiple organ pathology, gastrointestinal, and central nervous system toxicity

(2022) "Triple agonist reduces body weight and improves metabolic parameters in preclinical models." Published in Cell Metabolism

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A single ceramide doesn't do much on its own, since skin's barrier is actually made of several types working together