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Some of these factors predict lower GLP-1 responses (higher weight or BMI, and high glucagon concentrations), while others are determinants of enhanced GLP-1 secretion (older age, higher fasting NEFA concentrations)

The classical pathway is initiated by pathogenic stimuli, which activate pattern recognition receptors (PRRs) along with caspase recruitment domain- or pyrin domain-containing proteins (159, 163)

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