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PubMed Sigalos JT, Pastuszak AW

Itokazu M, Onodera Y, Mori T, Inoue S, Yamagishi K, Moritake A, et al

454 servings per pound (1 gram per serving)

The obese Zucker (fa/fa) rat provides a well-established animal model of insulin resistance and genetic obesity and, in comparison with lean Zucker rats, manifests hyperinsulinemia and hyperlipidemia

Looking here we can see that Retatrutide results are only about 4-5% shy of Sleeve Gastrectomy, an honest-to-god surgical procedure requiring general anesthesia