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Through the NHS for type 2 diabetes: NICE criteria include 4 : Inadequate control with other medications BMI of 35+ with obesity complications Or lower BMI where insulin would cause occupational issues Through the NHS for obesity: Very limited availability reserved for those with the greatest clinical need and a BMI of over 40
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In wild-type mice, FGF21 treatment increases hepatic transcription of the canonical oxidative stress response and antioxidant genes Sod2 (superoxide dismutase 2), Cat (catalase), Gpx1 (glutathione peroxidase 1), Sirt1 (sirtuin), and Foxo3 (forkhead box transcription factor 3) (151)
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Reduction of cardiovascular risk in selected adults with established cardiovascular disease and obesity or overweight, when specifically prescribed
