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The oestrogenhistamine feedback loop is particularly significant for women: This self-amplifying cycle explains why histamine intolerance symptoms are consistently worse in the days before menstruation (when oestrogen is relatively elevated and progesterone is falling), around ovulation, and during perimenopause when hormonal fluctuations intensify

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By blocking BCRP, harmine helps keep MXT inside cells for a longer period, providing insight into key mechanisms that contribute to drug resistance