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We observed CaOx crystal deposition, tubular dilatation, inflammatory cell infiltration, and apoptosis in the Gly group

DOI: 10.1016/j.bja.2019.04.061

In folic acid (FA)-induced AKI, Z-VAD-FMK, an inhibitor of apoptosis, could not reduce the damage to renal tubular epithelial cells, while the ferroptosis inhibitor Fer-1 effectively reduced oxidative stress and renal tubular cell death [136]

(3) Epigenetic modulation: Facilitates TET enzyme-mediated DNA demethylation and Jumonji domain-containing histone demethylase activity, linking micronutrient status to chromatin remodeling