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Gclc fl/fl mice were described previously 127 and were crossed to Mb1-Cre + expressing mice 46 to obtain the Gclc fl/fl Mb1-cre strain
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Biomolecules must cross the luminal lipid membranes that line the blood vessels and the brain parenchyma, in order to enter the brain because of the BBB limited permeability and the profusion of tight junctions that surround the endothelial cells [89]
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