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Future studies are needed to reconcile the underlying differences between tumor tissue and basal PTC cell line GPX4 expression levels and in vitro responses to pharmacologic inhibition of GPX4 within an emulated 3D thyroid tumor microenvironment in vitro and in vivo

Preclinical data indicate modulation of inflammatory and pro-fibrotic signalling pathways relevant to lung fibrosis, yet direct demonstration of reduced fibroblast activation or collagen deposition in established pulmonary fibrosis models is currently lacking

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Peter R et al

Adults & children over 12 years: 0.5-1 gm 4 times daily