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Diminished oxygen availability (hypoxia), as a hallmark of the TME, presents in the majority of tumors, arising from an imbalance between increased oxygen consumption and inadequate oxygen supply

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Circadian pathway Modulation of the circadian rhythm Regulates sleep-wake cycles Normalizes sleep disorders Effects lasting several days Opioid route Endogenous opioid system Pain perception module Blocked by naloxone Supports weaning management Stress response Hypothalamic-pituitary-adrenal axis Reduces stress responses Reduces cortisol secretion Improves stress management Unique biological properties Unlike most peptides, DSIP freely crosses the blood-brain barrier and can be absorbed by the intestine without enzymatic degradation

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Key findings: (1) Aged Fischer 344 rats showed restoration of spatial memory (Morris water maze) after subcutaneous Dihexa treatment at picomolar doses

Cancer Immunol Immunother