Centre for Addiction and Mental Health
#Alzheimers #Neurodegeneration #GLP1 #GLP1RA #Neuroscience #BrainHealth #DrugRepurposing #Biotech #Pharma #ClinicalTrials #AgingResearch #Dementia #LifeSciences #Neuroinflammation #HealthcareInnovation Repurposing glucagon-like peptide-1 receptor agonists for the treatment of neurodegenerative disorders - Nature Aging nature.com This feels similar to other disease areas where intervention timing made all the difference
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6% of patients in a matched cohort
267 GAS6, secreted by stromal cells such as CAFs and macrophages, binds to AXL, promoting its dimerization, autophosphorylation, and activation of downstream survival pathways, including the PI3K/AKT, MAPK/ERK, and NF-B pathways