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For an oral drug, the organ that receives the highest dose is the liver 50% of all drugs fail on liver toxicity Pfizer has not been so lucky
Nature 552 , 355361 (2017)
Consistent with other GLP-1 receptor agonists administered through subcutaneous injections, the most frequently recorded adverse events of oral semaglutide treatment were nausea and vomiting
Thats where microdosing GLP-1 comes in
Ulbricht C, Basch E, Szapary P, et al
It starts with a big dose to fill up the bodys stores
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