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10.1136/bmjdrc-2022-002919 3 Al-BiateM
& Laurindo, F
Safety signals identified through extended follow-up include: Gastrointestinal effects : Nausea, vomiting, and diarrhea remain the most common adverse events, typically diminishing over time but causing discontinuation in approximately 57% of patients Gallbladder disease : Increased incidence of cholelithiasis and cholecystitis, possibly associated with weight loss, though the exact mechanism remains under investigation Diabetic retinopathy : Risk of complications, particularly with rapid glycemic improvement in patients with pre-existing retinopathy Acute kidney injury : Risk associated with severe gastrointestinal adverse events leading to dehydration Pancreatitis : Rare cases reported, though causality remains uncertain
The NE concentration in the sample was measured using the Noradrenaline Research ELISA kit (BA-E-5200
For those dealing with insulin resistance or type 2 diabetes, semaglutide provides added benefits by improving blood sugar control
Current animal reproduction studies show no direct teratogenic effects at therapeutic doses, but human pregnancy data remains limited, making informed decision-making with your healthcare provider critical before conception
