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Multivariable linear regression analyses were performed to evaluate independent associations between treatment group and primary outcomes (% weight loss and HbA1c reduction at 6 months), adjusting for age, sex, baseline BMI, baseline HbA1c, and hepatosteatosis grade
2.3 GLP-1: from glucose-lowering strategy to a multi-system metabolic protection platform As a core incretin secreted by enteroendocrine L-cells, not only regulates insulin and glucagon secretion in a glucose-dependent manner but also serves as a central controller of energy homeostasis
Clinical evidence supporting this is mixed: IV glutathione shows consistent benefit in controlled trials, while oral forms show almost none unless formulated for enhanced absorption
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stopping treatment is often followed by weight regain
Through Weight Watchers Med+ , members can access licensed clinicians who determine whether prescription treatments are appropriate
