Ferroptosis-related genes that are transcriptionally regulated by Nrf2 have been reported, these include genes for GSH regulation (synthesis, cysteine supply via SLC7A11, GSH reductase, GPX4), NADPH regeneration which is critical for GPX4 activity [glucose-6-phosphate dehydrogenase (G6PD), phosphogluconate dehydrogenase, malic enzyme], and iron regulation (including iron export and storage, heme synthesis, and catabolism) (Abdalkader et al., 2018
Ultimately, in this case, I err on the side of some type of ban for both athletes
See the KLOW Stack guide for the full comparison
On top of that, the injectable form carries the same practical drawbacks as other injectable peptides: needles, sterile reconstitution, refrigeration, degradation after mixing, and the ongoing friction of maintaining a regular injection routine for benefits that build gradually over months
(6) Michael D Jensen (2006) Potential role of new therapies in modifying cardiovascular risk in overweight patients with metabolic risk factors Obesity (Silver Spring MD), 2006 Jun, Volume 14, Supplement 3, Pages 143S-149S
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