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| This weight loss drug is safe and effective | This will be the biggest blockbuster drug in history Until we have the full paper to read, its good to be skeptical here
Storage matters more here than it does for a robust small molecule, because peptides are fragile: heat, light, agitation and freeze-thaw cycles all degrade them, and a degraded peptide simply under-delivers with no visible warning
How strong is the evidence
PMID: 21381012
These drugs work by amplifying natural gut hormones that coordinate metabolism across multiple organ systems - the breakthrough came from Gila monster venom, which led to engineered peptides that last days instead of seconds