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If results are weak into the remodeling phase and starting dose was sub-3.2 mg, a dose increase and protocol modification may be warranted

1000 g IM daily or every other day for 12 weeks, then 1000 g once weekly for 48 weeks

NNMT (Nicotinamide N-Methyltransferase) is a cytosolic enzyme that catalyses the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide producing 1-methylnicotinamide (1-MNA) and S-adenosyl-homocysteine (SAH) as reaction products

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