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None of these has been studied in humans for the co-formulation, so the honest answer to what happens with sustained use? is simply: not established
GHK-Cu skin benefits GHK-Cu signals fibroblasts (the cells responsible for producing collagen and elastin) to ramp up production
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Mol Med Rep (2019) 20:23328
Reducing Signs of Ageing Like Fine Lines and Wrinkles The anti-ageing synergy reduces wrinkles, as evidenced by collagen studies showing dermal improvements
But not everyone should be taking these drugs, which can have serious side effects, including bowel obstruction, gallstone attacks and pancreatitis
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