The spore-forming single strain Clostridium butyricum (CBM588) improved progression-free survival and yielded higher response rates when added to nivolumab/ipilimumab in a randomized phase I study of metastatic renal cell carcinoma, and showed a further clinical activity signal when combined with nivolumab plus cabozantinib as first-line therapy, supporting a plausible immunomodulatory contribution of microbiome tuning to ICI outcomes [267, 268]
Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion
They found a useful target: glucagon-like peptide-1 (GLP-1), a gut hormone
Think of the first dose as an introduction rather than a quick fix
Properly labeled prescription containers significantly reduce screening delays at airport security checkpoints
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