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Animal research used weight-based dosing roughly in the range of 10 mcg per kg, which for a 80 kg human would be approximately 800 mcg per day, though extrapolation from rodent to human dose is not straightforward and this is not a clinical recommendation
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HACE is one of the most serious altitude-related conditions and is caused by swelling of brain tissue from fluid leakage and can lead to coma and death
Altern Med Rev 2011;16:355-364
Meron MK et al
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