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GLP-1 receptor agonists are not recommended for use in patients with severe gastrointestinal disease, including gastroparesis
The 48-week timeframe for retatrutide is shorter than the semaglutide and tirzepatide trials, which makes the comparison even more striking
It features two distinct structural modifications: the substitution of a Glutamic acid for an Arginine at position 3 (hence Arg3), and a 13-amino-acid extension piece at the N-terminus (hence Long)
If you are choosing between the two, our comparison of Semaglutide vs Berberine outlines the key differences in potency and expectations
If your body can't tolerate one GLP-1 drug, you may be able to try another
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