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J Biol Chem 292(2):597610
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Conclusion GLP-1 is a key hormone regulating appetite
In preclinical research, this dual mechanism has been investigated for its effects on insulin secretion, glucose homeostasis, appetite signaling pathways, and adipose tissue metabolism
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Given that alcohol exposure can cause histone modifications, such as acetylations and methylations, which may contribute to addiction pathophysiology (10, 11, 77, 78), our results suggest tirzepatide might influence epigenetic mechanisms involved in alcohol drinking behaviors
