Originally developed to treat type 2 diabetes, these therapies have become a breakthrough in weight management by mimicking the body's natural glucagon-like peptide-1 hormone
Semaglutide, a long-acting GLP-1 agonist, exhibited a sustained weight decrease of approximately 15% of body weight in clinical studies, whereas tirzepatide, a combination GIP/GLP-1 agonist, attained a weight loss of up to 22.5% in the SURMOUNT trials [36,37]
The deal reflects the growing commercial and legal complexity of the oral small-molecule space as companies move to protect pipeline assets ahead of potential future infringement claims
Nel A, Xia T, Mdler L, Li N (2006) Toxic potential of materials at the nanolevel
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