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Maintaining weight loss remains a challenge with GLP-1 drugs, as many patients experience weight regain once the treatment is discontinued or after prolonged use
Among the most important compensatory mechanisms is the platelet/megakaryocyte system responsible for hemostasis
Sci Transl Med 10(472):eaat3392 Jun LS, Millican RL, Hawkins ED, Konkol DL, Showalter AD, Christe ME, Michael MD, Sloop KW (2015) Absence of glucagon and insulin action reveals a role for the GLP-1 receptor in endogenous glucose production
While peptide-based GLP-1 receptor agonists such as Exenatide, Liraglutide, Dulaglutide, and Semaglutide have demonstrated strong efficacy, there remains significant interest in developing next-generation therapies
The SUSTAIN-6 trial showed cardiovascular benefit, which expanded the label in 2020
Start your intake Understanding GLP-1 Medication Costs in 2026 GLP-1 receptor agonists have transformed weight loss treatment, but brand-name options like Ozempic, Wegovy, and Mounjaro carry prices that often exceed $900 to $1,500 monthly even with insurance
