tirzepatide onset Time to of AEs in patients receiving Initial Tirzepatide Dose & Titration

Among people with pre-existing SUDs, initiation of GLP-1 receptor agonists was associated with reduced risk of SUD related emergency department visits (0.69 (0.61 to 0.78), NRD 8.92 (11.59 to 6.25)), SUD related hospital admissions (0.74 (0.65 to 0.85), NRD 6.23 (8.73 to 3.74)), and SUD related mortality (0.50 (0.32 to 0.79), NRD 1.52 (2.32 to 0.72)), and drug overdose (0.61 (0.42 to 0.88), NRD 1.49 (2.43 to 0.55)) and suicidal ideation or attempt (0.75 (0.67 to 0.83), NRD 9.95 (13.14 to 6.77))

According to FDA prescribing information, the most frequently reported adverse reactions include: Gastrointestinal symptoms: Nausea (24-30% of patients) often most pronounced after dose increases Vomiting (8-12% of patients) typically occurs when nausea is severe or unmanaged Diarrhea (18-24% of patients) can range from mild to moderate in severity Constipation (16-17% of patients) paradoxically occurs alongside diarrhea in some individuals Abdominal pain or discomfort (10-14% of patients) often described as cramping or bloating Dyspepsia (6-9% of patients) indigestion, heartburn, or upper abdominal discomfort Gastroesophageal reflux disease (5-7% of patients) Eructation (belching) (5-7% of patients) These symptoms frequently overlap and compound one another

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