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While singly-housed animals may experience stress that impacts metabolism, body weight, and adiposity 65,66,67,68,69 , the singly-housed animals in this study were treated identically (to the best of the experimenters ability) to minimize and equalize stress across all animals and reduce confounding variables

Reported Results in Preclinical Models Published rodent work reports reduced white adipose tissue mass in diet-induced obese models under NNMT inhibition, recorded without corresponding changes in food intake

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At best, about half of all patients become unresponsive to their current therapy and need to be switched up to another, more toxic drug

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