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Using RNA interference, we depleted cells of its transporter

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References Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, et al

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doi: 10.1080/15548627.2019.1634944 54 HuttoRABisbachCMAbbasFBrockDCCleghornWMParkerEDet al

Cell death in cancer cell lines To evaluate the ability of leading candidate proteases to induce cell death via procaspase-1 and gasdermin D cleavage, we stably integrated X(PC) and X(GD), as well as catalytically inactive variants as negative controls, into cancer cell lines under doxycycline-induced expression (Fig