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These dietary AGEs can be absorbed into the circulation and remain in the body long enough to cause tissue damage (Vlassara 2014

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Muric M, Nikolic M, Todorovic A, Jakovljevic V, Vucicevic K

But the annual cost of these drugs in the US upwards of $11,000 at recent list prices, though net prices may be lower with rebates negotiated by pharmacy benefit managers has raised concerns about the fiscal impact of broad coverage of GLP-1 drugs on Medicare, other health insurers, and patients