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[8] [9] The key difference between these medications lies in their mechanisms : Januvia enhances your body's own incretin system, whilst Rybelsus provides a synthetic incretin-like effect that is generally more potent

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The weight loss achieved varies by medication: semaglutide 2.4 mg typically produces 1215% weight reduction, whilst liraglutide 3.0 mg achieves approximately 58% weight loss when combined with lifestyle modifications, representing a substantial therapeutic advance in medical weight management

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