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When supplemented with an inactive form, it is converted to the active form in the body

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Norethisterone may cause side effects such as: headache nausea (feeling sick) breast tenderness changes in mood or sex drive unexpected bleeding When taking the combined pill, you may experience some side effects, such as: nausea or vomiting (feeling or being sick) dizziness breast tenderness mild headaches mood changes lower sex drive a change in your bleeding pattern (in the first 3 months of use) Both the combined pill and norethisterone can increase your risk of blood clots but if you have no other risk factors for blood clots your overall risk remains low

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NNMT normally methylates nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide and S-adenosylhomocysteine