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Slow titration appears to be the key to tolerability
What Is the Cellular Mechanism of SPI-1005 in Inner Ear Tissue
A Research Study Comparing a New Medicine Oral Semaglutide to Sitagliptin in People With Type 2 Diabetes (PIONEER 12)
A concrete example that clarifies this boundary is gastrin: multiple adequately powered human trials demonstrated that gastrin-based therapies failed to preserve beta-cell function in type 2 diabetes, and development was largely discontinued by approximately 2010
Some common side effects include stomach issues like nausea, vomiting, and diarrhea
Many patients tolerate these medications well, especially when doses are increased slowly
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