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People who take semaglutide (the active ingredient in Ozempic and Wegovy) or tirzepatide (Mounjaro) frequently report: Nausea Vomiting Constipation or diarrhea Fatigue Headaches Decreased appetite These side effects can be uncomfortable, but theyre generally short-term and manageable for most patients
2026;136(4):e194740
Edited by: Tavoloni N, Berk PD
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While the inflammation-reducing and fibrosis-attenuating effects of glucagon agonism are less well-characterized, the reductions in hepatic inflammation parameters and fibrosis observed in preclinical models likely reflect secondary effects consequent to improved steatosis, rather than direct anti-inflammatory actions [21]
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