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Meanwhile, long-term intracellular accumulation of platinum ions and persistent oxidative stress can activate the senescence program of renal tubular epithelial cells, induce cell cycle arrest and Senescence-Associated Secretory Phenotype (SASP), release a large number of pro-inflammatory and pro-fibrotic factors through paracrine effects, further amplify the local inflammatory response, and activate the proliferation and activation of renal interstitial fibroblasts (Nakao et al