Ocular side effects There is a reported increased risk of diabetic retinopathy with GLP-1 agonists, specifically semaglutide (Ozempic, Wegovy) as demonstrated by the SUSTAIN-6 trial (HR 1.76
That means even modest weight loss can dramatically reduce joint load and discomfort
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Safety Considerations and Future Outlook As with all pharmacotherapy for obesity and T2D, establishing cardiovascular safety and demonstrating improvements in meaningful clinical outcomes will be essential, particularly as cardiovascular outcome trials have not yet been completed with multi-agonists (although data are expected soon for tirzepatide: SURPASS-CVOT [T2D] in 2025
Another set of rats (n=5) in each group was applied to evaluate in vivo intestinal permeability
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