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These changes explain the range of gastrointestinal symptoms patients experience, from diarrhea to constipation

Both changes sit in the region that IGF binding proteins recognise, so the analogue binds IGFBPs far more weakly than IGF-I while retaining high affinity at the type 1 IGF receptor

Presented for research literature review only Gorozhanskaia EG et al

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Current research suggests these peptides work synergistically, with BPC-157 primarily driving angiogenesis and cytoprotection while TB-500 focuses on actin-mediated cellular migration and structural remodeling

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