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Individuals with Fitzpatrick skin types I or II (very fair, minimal natural melanin) often require higher initial doses (0.50.75mg) to overcome the naturally low baseline tyrosinase activity in their melanocytes
Zhang et al., 2010
The gain-of-function of mutant SOD1 toxicity has been also related to its ability to generate oxidants, as well as to a higher sensitivity of the enzyme to oxidants
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