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We synthesize current mechanistic and clinical observations within a framework of energy flux constriction and substrate proportionality, highlighting metabolic factors that may influence nutritional stability during sustained pharmacological weight reduction

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Getting the dose right matters: too little may do nothing, while more than needed wastes product without clearly improving results

We cross-referenced reported side effects and safety considerations across clinical literature and hormone-clinic resources

Lancet 2013;381:117124

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