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GLP-1 RAs, the levels of which are increased by food intake, bind to pancreatic -cell receptors and promote insulin synthesis and secretion
SCFAs activate free fatty acid receptors FFAR2 and FFAR3 on L-cells, thereby stimulating GLP-1 secretion
Full-dose uses the dosing range studied in large clinical trials for significant, sustained weight loss
References Collins, L
Izawa M, Taniguchi F, Terakawa N, Harada T
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