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Full optimization may take a few months and often improves after the second pellet cycle

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Discontinue if: Significant adverse reactions occur, you achieve body composition goals, no response after 8-12 weeks at optimal dosing, medical contraindications develop, or pregnancy occurs

For example, Melanotan II can increase the risk of melanoma

Retatrutide dosage escalation (Phase 2 trial protocol) The Phase 2 trial tested multiple starting dose strategies