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This final verification prevents concentration errors that affect all subsequent dosing from the vial

At the matrix level, abundant deposition of extracellular matrix (ECM) components and sustained activation of cancer-associated fibroblasts (CAFs) densify the stroma and create major physical barriers to the diffusion of nanoparticles and macromolecules [30, 32, 34]

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Journal of cutaneous pathology, 43(2), 142147