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This peptidergic interaction allows for fine control of the electrophysiological properties of NG neurons
In its Complete Response Letter, the FDA pointed to facility-related deficiencies discovered last month during an inspection of a third-party manufacturer as the reason for the rejection
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The advantage of small molecules over peptides is generally better oral bioavailability, improved stability, lower manufacturing costs, and easier pharmaceutical development
Observations of variable lean mass outcomes and dietary shifts during GLP-1RA therapy [40, 75] suggest that substrate availability may influence therapeutic durability even in the absence of overt deficiency
