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Resistance to osimertinib, a third-generation tyrosine kinase inhibitor targeting EGF receptor used as first-line therapy for patients with non-small cell lung cancer (NSCLC) harboring mutant EGFR, is mediated by IGF-1R signaling activated by IGF-2 in NSCLC cell lines (41)
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Researchers demonstrated protective effects against NSAID-induced gastric damage, alcohol-induced mucosal injury, and surgically created colonic defects 2
Mintziori G, Mousiolis A, Duntas LH, Goulis DG
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