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Have tried diet and exercise but struggle to maintain weight loss
A substudy within the Phase 2 trial also found that retatrutide reduced liver fat by up to 82% in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), formerly called fatty liver disease
Individuals often see the best outcomes when paired with lifestyle changes
However, extrapolating these findings to human physiology is problematic due to significant species differences in pancreatic anatomy, GLP-1 receptor distribution, and metabolic responses
Trial 2 Results at Week 26 in a Trial of RYBELSUS Compared to Empagliflozin in Adult Patients with Type 2 Diabetes Mellitus in Combination with Metformin a The intent-to-treat population includes all randomized patients
E., Gabler, N
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